PHARMACOLOGY (NEET 19)

1. Which is an oral factor Xa inhibitor? 

A. Rivaroxaban ✔️

B. Dabigatran

C. Argatroban

D. Frondaparinux

2. High plasma protein binding of a drug result in?

A. Increase in Vd

B. Decrease in glomerular filtration✔️

C. Increase in tubular secretion

D. Decreased drug interactions

3. Drug used for hypertensive and pulmonary edema due to scorpion sting?

a. Prazosin✔️

B. Clonidine

C. Furosemide

D. Mannitol

4. Iv mannitol is used for treatment of

a. Acute congestive glaucoma✔️

b. Pulmonary edema

c. Acute renal failure

d. CHF

5. Injection of all of the following drugs is painful except?

A. Propofol

B. Etomidate

C. Ketamine✔️

D. Methohexitone

6. Which intravenous anaesthetic agent doesn't cause cardiac depression?

A. Etomidate✔️

B. Ketamine

C. Propofol

D. Thiopentone

7. Dose of ulipristal for emergency contraception is

A. 30 mg ✔️

B. 30 mcg

C. 300 mg

D. 300 mcg

8. Most specific antiemetic for chemotherapy induced vomiting is?

A. Granisetron✔️

B. Tegaserod

C. Domperidone

D. Doxylamine

9. Drug of choice for mastitis is?

A. Cloxacillin✔️

B. Metronidazole

C. Amoxicillin

D. Cefazolin

10. FQ with highest oral bioavailability is 

A. Levofloxacin✔️

B. Gatifloxacin

C. Ciprofloxacin

D. Norfloxacin

11. Which of the following statements about fixed dose combination of drugs is true?

A. Adverse effect of one drug may be neutralized by the other✔️

B. In hepatic dysfunction, metabolism of both drugs is altered

C. Dose of one drug can be altered as per requirement

D. Adverse effect can be ascribed to a single drug

12. Which of the following is a K channel opener?

A. Nicorandil✔️

B. Ranolazine

13. A patient of RA is taking methotrexate, steroids and NSAIDs since 4 months but activity of disease progression is same. Next step i

A. Start monotherapy with anti TNF alpha drugs

B. Continue methotrexate and steroids

C. Stop oral methotrexate and start parenteral methotrexate

D. Add sulfasalazine & leflunomide✔️

14. Tolvaptan is used for

A. SIADH✔️

B. Central DI

C. Von Willebrand disease

D. Catecholamine resistant shock

15. Mechanism of action of oseltamivir is

a . Neuraminidase inhibition✔️

B. Inhibit thymidylate synthase

C. Inhibit RNA transcription

D. Inhibit uncoating of virus

16. Which drug used for differentiating myasthenia gravis from cholinergic crisis?

A. Edrophonium✔️

B. Neostigmine

C. Atropine

D. Acetylcholine

17. Mechanism of action of curare type drugs is?

A. Competitive inhibitor of ACh receptors✔️

B. Calcium channel blockade

C. Persistent depolarization of receptors

D. Blocking release of ACh

18. Buspirone acts on

A. 5HT1A✔️

B. 5 HT2

C. 5 HT3

D. 5 HT4

19. Carbapenem with maximum risk of seizures is

A. Imipenem✔️

B. Meropenem

C. Ertapenem

D. Doripenem

20. True statement about pegylated filgrastim is

A. It is given orally

B. It is GM-CSF

C. Reduces neutropenia✔️

D. Has short duration of action

21. True statement about teduglutide is

A. It is effective orally

B. It is GLP2 agonist✔️

C. It is a pancreatic enzyme

D. It is shorter acting because of degradation of  dipepdylpeptidase 4

22. Imipenem is combined with cilastatin to

A. Cilastatin prevents degradation of imipenem in kidney✔️

B. Cilastatin inreases absorption of imipenem.

C. Cilastatin inhibit beta lactmase activity

D. Both have synergystic activity against Pseudomonas

23. Mechanism of action of triazoles is

A. Inhibit ergosterol synthesis✔️

B. Inhibit mitotic spindle

C. Create pores in the membrane

D. Inhibit beta 1,3 glycan

24. Advantage of cisatracurium over atracurium is?

A. Short duration of action

B. Rapid onset

C. Less allergic

D. Releases less histamine ✔️

25. Drug used for smoking cessation is

A. Vareniciline✔️

B. Acamprosate

C. Naloxone

D. Sildenafil

26. Which of the following inhalational anaesthetic agent causes maximum respiratory irritation?

A. Enflurane

B. Halothane

C. Sevoflurane

D. Desflurane✔️

27. Which of the following statements about clinical trials is true

A. Phase 1 is done to determine efficacy in patients

B. Healthy volunteers are recruited for the first time in phase 2

C. Randomized controlled trial in patients is done in phase 3✔️

D. Phase 4 is a Pharmacokinetics study in animals

28. DoC for cyclospora (image) is

A. Cotrimoxazole✔️

B. Albendazole

C. Paromomycin

D. Metronidazole

29. Which of the following statements is not true?

A. Tamoxifen is drug of choice for post menopausal breast cancer and aromatase inhibitors are DOC✔️

for premenopausal breast cancer

B. Hormonal therapy is treatment of choice for postmenopausal breast cancer

C. Tamoifen is given as 2

D. 0 mg once a day for 5 years

30. Variation in sensitivity of response to a different doses of the drug in different individuals can be obtained from?

A. Quantal DRC✔️

B. Graded DRC

C. Potency

D. Efficacy

31. DOC for prophylaxis of diphtheria 

A. Erythromycin✔️

B. Rifampicin

C. Cloxacillin

D. Doxycycline

32. Drug causing ocular hypotension with apnea in an infant is

a. Latanoprost

B. Brimonidine✔️

C. Timolol

D. Acetazolamide

33. Which drug inhibit granulocyte migration?

A. Colchicine✔️

34. Drug of choice for ventricular tachycardia in a patient with Myocardial ischemia is

A. Lignocaine

B. Propanolol

C. Allopurinol