A.1-2%
B. 4-8%
C. 8-10%
D. 12-14%
Answer: B. 4-5%
▪️Consanguinity is a marriage between relatives and has various degrees.
▪️Closely related Individuals have higher chance of caring the same alleles than those less closely related and therefore children from consanguineous marriages are mere frequently homozygous for various alleles than those from non-consanguineous unions.
▪️Generally speaking, frequency of congenital malformations among newborns of first cousin unions is about 2 times the frequency among the general population in other words instead of a rate of 2-3% of birth defects in the gener population on the risk to first cousin couples is around 4-5%.
Q- Paired T test is defined ?
A. Test used to assess quantitative observations before and after an intervention
B.Test that is used when the observationare in the form of proportions
C. Test applied when separate observationsare made on individuals of two separate groups, and these need to be compared
D. None
Answer is A.Test used to assess quantitative observations before and after an intervention
▪️Test used to assess quantitative observations before and after an intervention is Paired t-tests.
▪️The paired t-test is used to compare the values of means from two related samples, for example in a before and after scenario.The difference between the means of the samles is unlikely to be equal to zero (duet to sampling variation) and the hypothesis test is designed to Answer the questons " Is the observed difference sufficiently large enough to indicate that the alternative hypothesis is true."
▪️The answer comes in the form a probability- the p-value
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